Research Articles
Essential Quality Control Metrics for Stem Cell Single-Cell RNA Sequencing Data: From Basics to Advanced Applications
This comprehensive guide details critical quality control (QC) metrics and analytical frameworks specifically tailored for single-cell RNA sequencing (scRNA-seq) data in stem cell research.
Evaluating Cellular Identity Preservation: From Foundational Concepts to Advanced Methods in Biomedicine
This article provides a comprehensive evaluation of methods for preserving and verifying cellular identity, a critical challenge in cell-based therapies and single-cell genomics.
Strategies for Addressing Batch Variation in Autologous Cell Therapy Manufacturing
This article provides a comprehensive guide for researchers and drug development professionals on managing batch variation in autologous cell products.
Engineering Hypoimmune Cells for Allogeneic Therapy: Strategies, Applications, and Clinical Frontiers
Allogeneic cell therapies derived from healthy donors or induced pluripotent stem cells (iPSCs) offer transformative potential for treating cancer, diabetes, and autoimmune diseases by providing 'off-the-shelf' availability.
Overcoming Immune Rejection in Allogeneic Cell Therapy: Strategies for 'Off-the-Shelf' Therapeutics
Allogeneic cell therapies offer a scalable, 'off-the-shelf' alternative to autologous treatments but face significant barriers from host immune rejection and graft-versus-host disease (GvHD).
Contamination Control in Cell Therapy Manufacturing: A 2025 Strategic Guide for Risk Reduction and Quality Assurance
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on establishing a robust contamination control strategy (CCS) for cell therapy manufacturing.
Non-Relapse Mortality in Allogeneic vs. Autologous Transplantation: Mechanisms, Trends, and Clinical Management
This article provides a comprehensive analysis of non-relapse mortality (NRM) following hematopoietic stem cell transplantation, contrasting the significantly higher risks associated with allogeneic (allo-SCT) versus autologous (auto-SCT) procedures.
Cell Expansion Protocols: A Strategic Guide to Autologous vs. Allogeneic Approaches for Researchers
This article provides a comprehensive analysis of cell expansion protocols for autologous and allogeneic therapies, tailored for researchers, scientists, and drug development professionals.
Autologous vs. Allogeneic Cell Therapy Manufacturing: Processes, Challenges, and Future Directions
This article provides a comprehensive analysis of the manufacturing processes for autologous and allogeneic cell therapies, tailored for researchers, scientists, and drug development professionals.
Integrating PK-PD Modeling and Natural Product Research: From Complex Challenges to Clinical Translation
This article provides a comprehensive overview of the application of Pharmacokinetic-Pharmacodynamic (PK-PD) correlation modeling in natural product research.