Research Articles
MSC Exosomes: Decoding the Bioactive Cargo Powering Next-Generation Regenerative Medicine
This article comprehensively reviews the molecular composition, mechanisms, and therapeutic applications of mesenchymal stem cell-derived exosomes (MSC-EVs) for researchers and drug development professionals.
A Comprehensive Guide to MSC-Derived Exosome Isolation: Mastering Ultracentrifugation Protocols for Research and Therapeutics
This article provides a detailed examination of ultracentrifugation for the isolation and purification of mesenchymal stem cell (MSC)-derived exosomes, a critical process in regenerative medicine and drug development.
Unveiling the Mechanisms: How MSC Exosomes Enter and Reprogram Keratinocytes and Endothelial Cells for Regenerative Therapy
This article provides a comprehensive analysis of the cellular uptake mechanisms of Mesenchymal Stem Cell (MSC)-derived exosomes by keratinocytes and endothelial cells, two critical cell types in cutaneous wound healing...
Unraveling the Mechanisms: How MSC-Derived Exosomes Target Molecular Pathways to Heal Chronic Wounds
Chronic wounds represent a significant clinical challenge due to their complex pathophysiology and failure to progress through normal healing stages.
Adipose-Derived Stem Cell Exosomes: Mechanisms and Therapeutic Applications in Angiogenesis and Neovascularization
This article comprehensively reviews the pivotal role of adipose-derived stem cell exosomes (ADSC-Exos) in promoting angiogenesis and neovascularization for therapeutic applications.
MSC Exosome Cargo Proteins: Master Regulators of Extracellular Matrix Remodeling in Regenerative Medicine
Mesenchymal stem cell-derived exosomes (MSC-Exos) have emerged as powerful, cell-free therapeutic agents in regenerative medicine.
MSC Exosomes as Immunomodulatory Agents: Mechanisms and Applications in M2 Macrophage Polarization
This article synthesizes current research on how mesenchymal stem/stromal cell (MSC)-derived exosomes orchestrate macrophage polarization toward the anti-inflammatory M2 phenotype.
MSC Exosomal miRNAs: Master Regulators of Fibroblast Proliferation and Migration in Regeneration and Disease
This article comprehensively explores the critical role of mesenchymal stem cell (MSC)-derived exosomal microRNAs (miRNAs) in regulating fibroblast proliferation and migration, a central process in tissue repair, regeneration, and pathology.
Targeting Chronic Inflammation: The Molecular Mechanism of MSC Exosomes in Diabetic Wound Healing
Diabetic wounds are characterized by a persistent inflammatory phase that prevents progression to healing, representing a significant clinical challenge.
Stem Cell-Derived Beta Cells for Type 1 Diabetes: A Comprehensive Review of Efficacy, Clinical Applications, and Future Directions
This article provides a comprehensive analysis of the efficacy of stem cell-derived beta cells as a curative therapy for type 1 diabetes (T1D), tailored for researchers, scientists, and drug development...