Research Articles
Engineering Immune Evasion: How HLA-E Knockin at the B2M Locus Confers NK Cell Protection in Allogeneic Cell Therapies
This article provides a comprehensive guide for researchers and drug developers on the innovative strategy of knocking HLA-E into the β2-microglobulin (B2M) locus to protect therapeutic cells from natural killer...
HIP CAR-T Efficacy in Immunocompetent Mouse Models: A Critical Guide for Translational Cancer Research
This article provides a comprehensive overview of evaluating HIP (Human Immune-Potentiating) CAR-T cell therapies in immunocompetent mouse models.
Engineering the Future of Cell Therapy: How Genetic Modification Supercharges MSC Immunomodulation
This article provides a comprehensive analysis for researchers and drug development professionals on leveraging genetic engineering to enhance the immunomodulatory potency of Mesenchymal Stromal Cells (MSCs).
Accelerating Discovery: How GPU-Accelerated Unsupervised Learning is Revolutionizing Atlas-Scale Single-Cell RNA-Seq Analysis
This article provides a comprehensive guide to GPU-based unsupervised machine learning for analyzing atlas-scale single-cell RNA sequencing (scRNA-seq) data.
Mastering GMP for Cell Therapy: A Comprehensive Guide to Compliant Manufacturing from Bench to Bedside
This article provides a definitive roadmap for researchers, scientists, and drug development professionals navigating the complex landscape of Good Manufacturing Practice (GMP) for cell therapies.
GMP Manufacturing for ATMPs: A Comprehensive Guide to Quality, Compliance, and Commercialization
This article provides a detailed, current overview of Good Manufacturing Practice (GMP) requirements for Advanced Therapy Medicinal Products (ATMPs), including cell and gene therapies.
GMP-Compliant iPSC-Derived Cardiomyocytes: Clinical Production, Quality Standards, and Therapeutic Applications
This comprehensive article addresses the critical pathway for translating iPSC-derived cardiomyocytes from research to clinical applications.
Ensuring Safety in Cell Therapies: GMP-Compliant Differentiation Strategies to Eliminate Residual Human Pluripotent Stem Cells
This article provides a comprehensive guide for researchers and drug development professionals on designing and implementing Good Manufacturing Practice (GMP)-compliant differentiation protocols for human pluripotent stem cells (hPSCs).
Building a GMP-Compliant Autologous iPSC Manufacturing Pipeline: A Comprehensive Guide for Clinical Translation
This article provides a detailed, step-by-step guide for researchers, scientists, and drug development professionals aiming to establish a robust, Good Manufacturing Practice (GMP)-compliant workflow for autologous induced pluripotent stem cell...
Decoding Immune Regulation: A Comprehensive Flow Cytometry Guide to MSC Immunomodulatory Analysis
This article provides a detailed guide for researchers, scientists, and drug development professionals on using flow cytometry to analyze the immunomodulatory effects of Mesenchymal Stromal Cells (MSCs).