Research Articles
Navigating the Double-Edged Sword: Strategies to Control Cellular Senescence in Reprogramming for Regenerative Medicine
Cellular reprogramming, while holding immense potential for rejuvenation and regenerative medicine, is intrinsically linked to cellular senescence—a process that acts both as a barrier and a paradoxical facilitator.
Optimizing Dosing Regimens for Epigenetic Modulators: A Strategic Guide to Maximizing Therapeutic Windows
This article addresses the critical challenge of dosage optimization for epigenetic modulators, a pivotal factor in translating their therapeutic promise into clinical success.
Balancing the Clock: Optimizing Reprogramming Duration to Maintain Cell Identity and Function
This article provides a comprehensive guide for researchers and drug development professionals on the critical challenge of optimizing cellular reprogramming duration.
Controlling Dedifferentiation in Cellular Rejuvenation: Strategies for Safe Reprogramming and Therapeutic Application
This article provides a comprehensive analysis for researchers and drug development professionals on the critical challenge of controlling dedifferentiation in cellular rejuvenation therapies.
Harnessing Epigenetic Reprogramming to Prevent Tumorigenesis: Mechanisms, Therapeutics, and Clinical Frontiers
This article provides a comprehensive analysis for researchers and drug development professionals on leveraging epigenetic reprogramming to prevent cancer initiation.
Chemical Induction of Pluripotency: Mechanisms, Methods, and Clinical Applications in Regenerative Medicine
This article comprehensively reviews the rapidly advancing field of chemical reprogramming, a non-genetic approach for generating human induced pluripotent stem cells (iPSCs) using small molecules.
Advanced Biomaterials for Epigenetic Modulator Delivery: From Smart Nanocarriers to Clinical Translation
This article provides a comprehensive analysis of the rapidly evolving field of biomaterial-mediated delivery of epigenetic modulators.
Matrix Rigidity as an Epigenetic Switch: Engineering Cell Fate for Regeneration and Disease Modeling
The extracellular matrix (ECM) is no longer viewed as merely a structural scaffold; its mechanical properties, particularly rigidity, are now recognized as potent regulators of the cellular epigenome.
Three-Dimensional Microenvironments: Revolutionizing Cellular Reprogramming for Regenerative Medicine and Drug Discovery
This article explores the transformative role of three-dimensional (3D) microenvironments in enhancing the efficiency and functionality of cellular reprogramming.
In Vivo Yamanaka Factor Delivery: Methods, Applications, and Safety for Therapeutic Reprogramming
This article provides a comprehensive analysis of current methods for delivering Yamanaka factors (OCT4, SOX2, KLF4, c-MYC) for in vivo reprogramming, a transformative approach in regenerative medicine.