Research Articles
Patient-Specific Disease Modeling with hiPSCs: From Mechanisms to Clinical Translation
Human induced pluripotent stem cells (hiPSCs) have revolutionized biomedical research by enabling the generation of patient-specific cellular models for a wide range of diseases.
MSC-Derived Exosomes in Wound Healing: Mechanisms, Clinical Translation, and the Future of Cell-Free Therapy
This article provides a comprehensive analysis of the role of mesenchymal stem cell (MSC)-derived exosomes in wound healing, tailored for researchers, scientists, and drug development professionals.
Unraveling the Mechanisms of Mesenchymal Stem Cell Immunomodulation: From Basic Science to Clinical Applications
This article provides a comprehensive analysis of the molecular and cellular mechanisms underlying mesenchymal stem cell (MSC)-mediated immunomodulation, a rapidly advancing field with significant therapeutic potential.
Herbal Medicine Standardization: Advanced Methods for Quality Control and Evidence-Based Research
This article provides a comprehensive overview of contemporary standardization methods for herbal medicine preparations, tailored for researchers, scientists, and drug development professionals. It explores the foundational necessity of quality control for ensuring safety and efficacy, details advanced methodological approaches from pharmacognosy to modern analytics, addresses key challenges in research and regulation, and evaluates validation frameworks and comparative regulatory landscapes. By synthesizing traditional knowledge with cutting-edge scientific rigor, this review aims to bridge the gap between herbal medicine and mainstream pharmaceutical development, promoting reproducible, high-quality, and evidence-based herbal products.
Regenerative Pharmacology: Mechanisms of Action for Curative Therapeutics
This article explores the emerging paradigm of regenerative pharmacology, a field dedicated to developing curative therapies that restore the structure and function of damaged tissues and organs, moving beyond symptomatic management. Aimed at researchers, scientists, and drug development professionals, it provides a comprehensive analysis of the foundational principles, key mechanisms of action, and advanced methodologies driving this discipline. The content delves into the integration of pharmacology with systems biology and regenerative medicine, examines the pharmacological toolkit for directing tissue regeneration, addresses critical translational and manufacturing challenges for Advanced Therapy Medicinal Products (ATMPs), and outlines the rigorous validation and comparative frameworks necessary for clinical success. By synthesizing current research and future directions, this article serves as a strategic guide for navigating the complexities of creating transformative regenerative pharmacotherapies.
Timing is Everything: Strategic Control of Reprogramming Factor Expression for Efficient Cell Fate Conversion
This article provides a comprehensive analysis of the critical role that the timing, dynamics, and stoichiometry of reprogramming factor expression play in directing cell fate. Tailored for researchers and drug development professionals, it synthesizes foundational principles, current methodological applications, and optimization strategies. The scope ranges from mastering the core molecular mechanisms and leveraging computational tools for factor discovery, to implementing precise temporal control via chemical and genetic systems for enhanced efficiency and safety. It further explores the critical balance between rejuvenation and tumorigenicity in therapeutic contexts, supported by comparative validation of in vivo models and single-cell omics. This resource is designed to guide the rational development of robust and clinically viable reprogramming protocols.
Biomimetic Scaffold Design for Extracellular Matrix Mimicry: From Decellularization to 3D Bioprinting in Tissue Engineering and Drug Development
This article provides a comprehensive analysis of advanced strategies for designing extracellular matrix (ECM)-mimicking scaffolds, a cornerstone of modern tissue engineering and regenerative medicine. It explores the foundational biology of the native ECM and its critical role in guiding cell behavior. The scope extends to detailed methodologies for scaffold fabrication, including decellularization techniques and multidimensional bioprinting, alongside their applications in regenerating tissues such as skin, bone, and cartilage, as well as in creating physiologically relevant tumor models for drug screening. The content further addresses key challenges in scaffold optimization, standardization, and immune response modulation. Finally, it covers validation frameworks and comparative analyses of scaffold types, offering researchers and drug development professionals a holistic resource to bridge the gap between laboratory innovation and clinical translation.
Mitochondrial Dysfunction in Cellular Aging: From Molecular Mechanisms to Emerging Therapeutic Strategies
Mitochondrial dysfunction is a established hallmark of the aging process, contributing significantly to cellular senescence and the pathogenesis of age-related diseases. This article synthesizes current research for a scientific audience, exploring the foundational mechanisms—including mtDNA instability, reactive oxygen species (ROS) production, and impaired mitophagy—that drive aging. It further examines methodological approaches for assessing mitochondrial health, critically analyzes emerging therapeutic interventions targeting mitochondrial quality control, and validates strategies through recent preclinical and clinical evidence. By integrating these four intents, this review provides a comprehensive framework for understanding mitochondrial biology in aging and its implications for developing novel gerotherapeutic interventions.
The Salt Solution: How Scientists Are Revolutionizing Cartilage Repair with Collagen Bioinks
Discover how collagen bioinks with optimized ionic strength are transforming cartilage tissue engineering and regenerative medicine.
Revolutionizing Medicine: How Induced Pluripotent Stem Cells are Powering the Future of Drug Development
Explore how induced pluripotent stem cells (iPSCs) are transforming drug development through personalized disease modeling, high-throughput screening, and innovative therapeutic approaches.